Nutritional supplement

Composition
One capsule contains 150 mg of 5-hydroxytryptophan (5-HTP).


Recommendations for use:
• sleep disorders, impaired mood,
• in order to keep normal brain function and good nervous system performance,
• to relieve headache.

Action of active substances
5–HTP
5-HTP (5-hydroxytryptophan) is a product of tryptophan dissociation. It is necessary to consume large amount of L-tryptophan containing products for our organism to produce enough of 5-hydroxytryptophan. So everybody who lacks this substance should supplementary use 5-HTP.
5-hydroxytryptophan is obtained from the seeds of a plant Griffonia simplicifolia that grows in Africa. 5-hydroxytryptophan is transformed to serotonin in the organism. It is an active substance that influences mood, working capacity, positive emotions, circadian sleep rhythm. 5-hydroxytryptophan effectively improves mood and sleep, relieves headache and muscle pain, improves nervous system performance, helps to reduce weight because it diminishes appetite.
5-HTP improves mood, reduces migraine and fibromyalgia
Newest scientific research proves that MAO activity (monoaminoxidase – enzyme that ferments serotonine) is significantly increased in persons with migraine attack. It was proved after the serotonin metabolite (5-HIAA) was found in urine of the persons with migraine. In the beginning the assumption was that the metabolites appear in urine because of the increased amount of serotonin. However, later the conclusion was made that everything is in opposite way – serotonin is dissociated abnormally fast. It is thought that low serotonin amount decreases pain threshold for persons with migraine. 5-HTP also decreases migraine pain intensity and frequency.
5-HTP improves sleep
Melatonin is important to sleep. Scientific research proves that 5-HTP shortens the time needed to fall asleep and lowers the number of awakenings during the night.
5-HTP helps to reduce weight
Data show that 600-900 mg of 5-HTP diminish the appetite, fat absorption and stimulates weight loss. It is possible to lose 5 kilograms of weight in three months.

Scientific researches demonstrating the efficiency
* 13 studies out of 17 that were reviewed confirmed that 5-HTP has antidepressant properties. (Zmilacher K, et al. L-5-hydroxytryptophan alone and in combination with a peripheral decarboxylase inhibitor in the treatment of depression. Neuropsychobiology 1988;20:28-35.)
*Rome university scientists performed double-blind placebo controlled study with 20 overweight women. They were administered 300 mg of 5-HTP and placebo for 6 months. A significant weight loss was noticed in the 5-HTP group and no such effect was observed in placebo group. [7].
* Double-blind study in Switzerland 1991 showed that 5-HTP and tricycle antidepressants effectiveness in treatment of moderate depression is almost equal. [7].
* The study of 5-HTP effect on sleep showed that administration of 600 mg 5-HTP shortens the time needed to fall asleep and improves the quality of the sleep [7]. It is because 5-HTP increases serotonin concentration that has tiredness inducing property and stimulates melatonin production. [21].
* 124 patients with migraine headache study showed that 5-HTP in 70 percent of cases decreased headache intensity and frequency. [7].

Warning: consult a doctor before using this medicine together with antidepressants or other nervous system affecting medicines.

Literature:
1. Pharmacol Biochem Behav. 2003 Mar;74(4):877-82. Selective augmentation of genioglossus electromyographic activity by L-5-hydroxytryptophan in the rat. Berry RB, Hayward LF.
2. Altern Med Rev. 2000 Feb;5(1):64-71. Use of neurotransmitter precursors for treatment of depression. Meyers S.
3. Biol Pharm Bull. 2003 Oct;26(10):1491-3. Effects of insulin and adrenalectomy on elevation of serum leptin levels induced by 5-hydroxytryptophan in mice. Yamada J, Sugimoto Y, Ujikawa M.
4. Eur J Pharmacol. 2000 Oct 6;406(1):159-62. Serum leptin levels after central and systemic injection of a serotonin precursor, 5-hydroxytryptophan, in mice. Yamada J, Ujikawa M, Sugimoto Y.
5. Chin J Physiol. 1995;38(4):235-40. Serotonergic mechanisms involved in the suppression of feeding by 5-HTP in rats. Ju CY, Tsai CT.
6. Int J Obes Relat Metab Disord. 1998 Jul;22(7):648-54. Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients. Cangiano C, Laviano A, Del Ben M, Preziosa I, Angelico F, Cascino A, Rossi-Fanelli F.
7. Altern Med Rev. 1998 Aug;3(4):271-80. 5-Hydroxytryptophan: a clinically-effective serotonin precursor. Birdsall TC.
8. Adv Exp Med Biol. 1996;398:35-41. Brain Serotonin, Carbohydrate-craving, obesity and depression. Wurtman RJ, Wurtman JJ.
9. Brain Res. 1991 Aug 2;555(2):245-50. Involvement of corticotrophin releasing factor (CRF) in the thermogenic and anorexic actions of serotonin (5-HT) and related compounds. Le Feuvre RA, Aisenthal L, Rothwell NJ.
10. Eur J Pharmacol. 1999 Oct 21;383(1):49-51. The serotonin precursor 5-hydroxytryptophan elevates serum leptin levels in mice. Yamada J, Sugimoto Y, Ujikawa M.
11. Int J Obes. 1987;11 Suppl 3:109-23. Medial hypothalamic serotonin in the control of eating
behavior. Leibowitz SF, Weiss GF, Shor-Posner G.
12. Neurosci Lett. 1992 May 11;139(1):53-6. Alpha 2-adrenoceptor modulation of 5-HT biosynthesis in the rat brain. Yoshioka M, Matsumoto M, Togashi H, Smith CB, Saito H.
13. Life Sci. 2003 Sep 19;73(18):2335-44. Hyperleptinemia elicited by the 5-HT precursor, 5-hydroxytryptophan in mice: involvement of insulin. Yamada J, Sugimoto Y, Ujikawa M, Goko H, Yagura T.
14. Aust N Z J Psychiatry. 2002 Aug;36(4):488-91. Are tryptophan and 5-hydroxytryptophan effective treatments for depression? A meta-analysis. Shaw K, Turner J, Del Mar C.
15. Endocr Rev. 1996 Apr;17(2):187-205. Antidepressants and hypothalamic-pituitary-adrenocortical regulation. Holsboer F, Barden N.
16. Psychoneuroendocrinology. 2004 May;29(4):423-47. Do antidepressants regulate how cortisol affects the brain?
Pariante CM, Thomas SA, Lovestone S, Makoff A, Kerwin RW.
17. J Clin Psychopharmacol. 2002 Apr;22(2):183-9. Placebo-controlled comparison of three dose-regimens of 5-hydroxytryptophan challenge test in healthy volunteers. Gijsman HJ, van Gerven JM, de Kam ML, Schoemaker RC, Pieters MS, Weemaes M, de Rijk R, van der Post J, Cohen AF.