Nutritional supplement
Composition
One capsule contains:
Recommendations for use:
- to relieve the symptoms of menopause or premenstrual period,
- in case of cardiovascular diseases.
Action of active substances
Isoflavone
Isoflavones are called natural estrogens because they bind to the estrogen receptors and act similar to estrogen. Isoflavones relieve the symptoms of menopause, regulate hormone level during the premenopausal period, are effective in case of osteoporosis. Isoflavones - genistein and daidzein have antioxidative and phytoestrogenic properties. Isoflavones may help to prevent malignant diseases, to reduce blood cholesterol level significantly, improve blood circulation, relieve inflammation, strengthen immunity.
Scientific researches demonstrating the efficiency
* Researchers of Dunn Nutrition Center, England on the year 1995, studied women of premenopausal age for 9 months. They noticed that when using isoflavones the blood cholesterol level was reduced, sexual hormones metabolism was improved and menstruation cycle became regular.
* Administration of isoflavones for 5-6 weeks without any changes in diet reduce the blood bad cholesterol level and increase the blood good cholesterol concentration, bone density increases, risk of osteoporosis decreases. (Year 1999, Copenhagen Pan institute, Michael Hospital, Toronto, University of North Carolina, Year 1998 - College of Baylor, Houston and University of Illinois, Year 1995 - England Nutrition Center).
* Premenopausal age women were administered isoflavones for one month. It was noticed that isoflavones regulate the menstruations cycle: during ovulation they decrease the amount of luteinizing hormone and follicle stimulating hormone, increase the concentration of estradiol and reduce the blood cholesterol concentration.
The effect of isoflavones is similar to the effect of antiestrogenic drugs. (Cassidy A, Bingham S, Setchell KD. Am J Clin Nutr. 1994 Sep;60(3):333-40.)
* Double blind, placebo controlled, randomized trials with 200 women of postmenopausal age were performed. Bone mineral density was measured at the beginning of the trial and after 1 year. One group of women used isoflavones ant the other group - placebo. All women were administered calcium and vitamin D3. Bone mineral density of the women that used isoflavones was decreasing very slowly , they had lower risk to develop osteoporosis. (Chen YM et al. J Clin Endocrinol Metab. 2003 Oct;88(10):4740-7)
Dosage
1 capsule 2 times a day.
Literature:
1.Cassidy A, Bingham S, Setchell KDR. Biological effects of soy protein rich in isoflavones on menstrual cycle of premenopausal women. Am J Clin Nutr 1994; 60:333-340.
2.Anderson JW, Johnstone BM, Cook-Newell ME. Meta-analysis of the effects of soy protein intake on serum lipids. N Engl J Med. 1995;333(5):276-282.
3.Weggemans RM, Trautwein EA. Relation between soy-associated isoflavones and LDL and HDL cholesterol concentrations in humans: a meta-analysis. Eur J Clin Nutr. 2003;57(8):940-946.
4.Squadrito F, Altavilla D, Crisafulli A, et al. Effect of genistein on endothelial function in postmenopausal women: a randomized, double-blind, controlled study. Am J Med. 2003;114(6):470-476.
5. Nestel PJ, Yamashita T, Sasahara T, et al. Soy isoflavones improve systemic arterial compliance but not plasma lipids in menopausal and perimenopausal women. Arterioscler Thromb Vasc Biol. 1997;17(12):3392-3398.
6. Hale GE, Hughes CL, Robboy SJ, Agarwal SK, Bievre M. A double-blind randomized study on the effects of red clover isoflavones on the endometrium. Menopause. 2001;8(5):338-346.
7.Simons LA, von Konigsmark M, Simons J, Celermajer DS. Phytoestrogens do not influence lipoprotein levels or endothelial function in healthy, postmenopausal women. Am J Cardiol. 2000;85(11):1297-1301.
8.Steinberg FM, Guthrie NL, Villablanca AC, Kumar K, Murray MJ. Soy protein with isoflavones has favorable effects on endothelial function that are independent of lipid and antioxidant effects in healthy postmenopausal women. Am J Clin Nutr. 2003;78(1):123-130.
