Nutritional supplement

Composition

One capsule contains:

• Potassium citrate (307 mg of Potassium)  820 mg.

Recommendations for use:

• in order to replenish the missing amount of kalium in the organism,
• while eating an inferior food,
• while taking exercises intensively,
• while sweating strongly,
• in case of heartbeat disorders, which appear because of the lack of kalium,
• in case of muscles pain and weakness.

Influence of active materials

Kalium

Kalium is one of the most important cations of the organism, which takes part in the circulation of nerve impulse and maintenance of normal pH of the organism, osmotic pressure of cells, irritability and other functions. Large amounts of kalium are found in potatoes, bananas, avocados, melons, raisins, oranges, spinaches, beans, meat, milk and cheese.
Circulation of kalium in the organism is regulated by hormones of adrenal cortex and kidney. Kalium influences the function of cells of pervious heart muscle and nerve impulse system, stimulates cells irritability of skeleton transversely striated muscles and ensures contraction of these muscles. Preliminary 98 % of kalium concentrate in cells and only 0,4 % in the serum of blood. For particular reason the amount of kalium in cells and blood may decrease – whereupon develops hypokalemia. This can happen while using some of the diuretics, glycosides that affect hart, while vomiting, scouring, eating inferior food, starving, strongly sweating, in case the amount of magnesium decreases (magnesium is necessary for normal adoption of kalium and it‘s circulation), frequently using alcohol, taking exercises intensively. In case the amount of kalium in the organism decreases, the whole organism becomes week, emerge disorders of heartbeat, muscles pain and weakness, constipation, raging thirst, hypotension, the skin becomes very dry. Kalium citrate less than other kalium salts irritates stomach, do not induce sudden lifts of kalium concentration in the blood, makes urine to be more alkaline and blocks renal calculus formation (By David S Goldfarb, M.D Director, Kidney Stone Prevention Program, St. Vincents Hospital Professor of Medicine and Physiology, NYU School of Medicine).

Researches:

*For 43000 men were appointed 4,3 g of kalium per day for 8 years (including the amount of kalium, received together with food) and it was noticed that the risk of heart attacks decreased for 62 % in comparison with those men, who used two times less of kalium. This was especially noticeable for those, who had hypertension (Ascherio A, Rimm EB, Hernan MA, et al. Intake of potassium, magnesium, calcium, and fibber and risk of stroke among US men. Circulation. 1998;98(12):1198-1204. (PubMed)).
*After accomplishing 4 large researches it was noticed a direct interconnection between medicines that include kalium and mineral density of the bones. For women of menopause age and men, older than 40 years, were appointed 3–3,5 g of kalium per day (including the amount of kalium, received together with food) and it was noticed that mineral density of bones has increased while using medicines that include kalium, because of reduction of kalium excretion (Tucker KL, Hannan MT, Chen H, Cupples LA, Wilson PW, Kiel DP. Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. Am J Clin Nutr. 1999;69(4):727-736. (PubMed)).
* For 45 000 men were appointed about 4 g of kalium per day for 4 years (including the amount of kalium, received together with food) and it was noticed that the risk of formation of kidney stones was 50 % lesser than using two times smaller dose (Curhan GC, Willett WC, Rimm EB, Stampfer MJ. A prospective study of dietary calcium and other nutrients and the risk of symptomatic kidney stones. N Engl J Med. 1993;328(12):833-838. (PubMed)).
* The metanalysis of 33 randomised researches, accomplished in 1997, has showed that the usage of kalium preparations makes an influence to the pressure of blood (Whelton PK, He J, Cutler JA, et al. Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials. JAMA. 1997;277(20):1624-1632.).
* For 150 people with limitary blood pressure (140/ 90 mmHg) were appointed 0,5 g of kalium preparation per day for 3 months and it was noticed that systolic blood pressure declined for 5 mm Hg. There was no such effect in the placebo group (Whelton PK, He J, Cutler JA, et al. Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials. JAMA. 1997;277(20):1624-1632.).

Dosage

To take 1 capsule 1 - 2 times per day.

Literature:

1. Peterson LN. Potassium in nutrition. In: O'Dell BL, Sunde RA, eds. Handbook of nutritionally essential minerals. New York: Marcel Dekker, Inc; 1997:153-183.
2. Sheng H-W. Sodium, chloride and potassium. In: Stipanuk M, ed. Biochemical and Physiological Aspects of Human Nutrition. Philadelphia: W.B. Saunders Company; 2000:686-710.
3. Genn ari FJ. Hypokalemia. N Engl J Med. 1998;339(7):451-458.
4. Young DB, Lin H, McCabe RD. Potassium's cardiovascular protect mechanisms. Am J Physiol. 1995;268(4 Pt 2):R825-837 Pharmacology manual, 1986m., page 291.